Pair Name | Ginger extract, Doxorubicin | ||
Phytochemical Name | Ginger extract (PubChem CID: / ) | ||
Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Ginger extract, Doxorubicin | |||
Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Down-regulation | Expression | CCND1 | hsa595 |
Down-regulation | Expression | NFKB1 | hsa4790 | |
Up-regulation | Phosphorylation | PRKAA1 | hsa5562 | |
Up-regulation | Expression | TP53 | hsa7157 | |
In Vivo Model | 1×10⁶ EAC cells were implanted subcutaneously into the right thigh of the lower limb of mice. | |||
Result | AMPK pathway and cyclin D1 gene expression could be a molecular therapeutic target for the anticancer effect of GE in mice bearing SEC. Combining GE and DOX revealed a greater efficacy as anticancer therapeutic regimen. |
No. | Title | Href |
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1 | Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms. Eur J Nutr. 2018 Apr;57(3):981-989. doi: 10.1007/s00394-017-1382-6. | Click |