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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Ginger extract, Doxorubicin
Phytochemical Name Ginger extract (PubChem CID: / )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 583
Pair Name Ginger extract, Doxorubicin
Disease Info [ICD-11: 2A00-2F9Z] Solid tumour or cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression CCND1 hsa595
Down-regulation Expression NFKB1 hsa4790
Up-regulation Phosphorylation PRKAA1 hsa5562
Up-regulation Expression TP53 hsa7157
In Vivo Model 1×10⁶ EAC cells were implanted subcutaneously into the right thigh of the lower limb of mice.
Result AMPK pathway and cyclin D1 gene expression could be a molecular therapeutic target for the anticancer effect of GE in mice bearing SEC. Combining GE and DOX revealed a greater efficacy as anticancer therapeutic regimen.
03. Reference
No. Title Href
1 Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms. Eur J Nutr. 2018 Apr;57(3):981-989. doi: 10.1007/s00394-017-1382-6. Click
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